Microextração em fase sólida para análise de fármacos em fluidos biológicos

Queiroz, Maria Eugênia C.

Palavras-chave: solid-phase microextraction, drugs, biological samples.

Resumo: The theoretical aspects of solid-phase microextraction (SPME), and general overview of the important factors in the optimization of extraction efficiency such as coating (stationary phase) fiber types, extraction time, matrix pH, ionic strength, effect of organic additives, temperature, degree of agitation, influence of protein, and desorption conditions are discussed. The recent published applications and method validation issues are also described in the areas of pharmaceutical, biomedical, and social toxicology.


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