GC-MS: Más de un analizador de masas, ¿para qué?
Stashenko, Elena E.; Martínez, Jairo R.
Palavras-chave: GC, GC-MS, MSD, tandem, quadrupole (Q), triple quadrupole (QQQ, QqQ).
Resumo: The purpose and advantages of having more than one mass analyzer are explained in terms of sensitivity, selectivity and, particularly, specificity, an additional descriptor of the enhanced performance that a GC-MS/MS system achieves. The particular features of the triple quadrupole (QQQ or QqQ) system are highlighted and its various operation modes are described in order to explain the origin of this performance enhancement. Depending on the particular operation mode, the mass spectrometer with triple quadrupole may be a universal detector (full scan), a selective detector (SIM), or a highly-specific detector (MRM-mode), with concomitant gains in the signal/noise ratio, in comparison with a single quadrupole system.
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