Recent advances on in-tube SPME-LC for bioanalysis

Queiroz, Maria Eugênia C.; Melo, Lidervan P.

Palavras-chave: In-tube solid-phase microextraction, drugs, biological fluids, selective stationary phases.

Resumo: On-line in-tube SPME-LC performed continuous extraction, concentration, desorption, and injection using an autosampler. This technique is usually used in combination with high performance liquid chromatography and liquid chromatography-mass spectrometry. This technique has successfully been applied to the determination of drugs in biological fluids. In this review, the authors discuss the recent advances in the development of selective stationary phases to increase the sensitive of the chromatography methods for bioanalysis.

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