Automatic on-chip sample processing prior to chromatographic separations

Miró, Manuel

Palavras-chave: Meso/microfluidics, chromatography, on-chip sample pretreatment, microsolid-phase extraction, automation.

Resumo:  In this review, mesofluidic Lab-on-a-Valve (LOV) platforms as the new generation of flow systems resulting from the combination of micro-flow Injection analysis and Lab-on-a-Chip are presented for automatic handling of samples and their pretreatment prior to chromatographic and electrophoretic separations. Miniaturization and integration of on-chip solid-phase extraction procedures within LOV using disposable (single-use) sorbent is explained in detail. Interfaces designed in the literature for coupling LOV with liquid and gas chromatography and capillary electrophoresis are overviewed and exemplified via representative applications in the environmental and bioanalytical fields.

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