http://dx.doi.org/10.4322/sc.2016.010
LC-MS/MS determination of chloramphenicol in food of animal origin in Brazil
Guidi, Letícia R.; Silva, Luiza H. M.; Fernandes, Christian; Engeseth, Nicki J.
Palavras-chave: antibiotic, milk, fish, honey, liquid chromatography, mass spectrometry.
Resumo: Chloramphenicol is a highly efficient antibiotic with broad spectrum activity. It has been banned from food producing animals because of serious adverse effects to human health. Nevertheless, it is still being used in some countries because of its high efficacy and relatively low price. There is currently a minimally required performance limit (MRPL) defined at 0.3 mg/kg. This is the reason why chloramphenicol has often been analyzed by highly efficient and sensitive single residue methods. The objective of this review is to provide the state-of-art scientific knowledge on chloramphenicol, the LC-MS/MS methods used for its analysis and its occurrence in foods of animal origin in Brazil.
Referências Bibliográficas
[1] JECFA, Who Food Additives Series, 53, 1–40, (2014).
[2] J.V. Samsonova, A. Cannavan and C.T. Elliott, Rev. Anal. Chem., 42, 50–78, (2012).
[3] J.C. Hanekamp and A. Bast, Environm. Toxicol. Pharmacol., 39, 213–220 (2015)
[4] A. Gentili, S. Perret and S. Marchese, Trends Anal. Chem., 24(7), 704–733, (2005).
[5] B. Berendsen, Anal. Bioanal. Chem., 397, 1955–1963 (2010).
[6] M. Splendore, C. Kellogg and R. Thakur, Food Saf. Mag., June 7, (2013).
[7] CAS (2015) http://www.commonchemistry.org/ChemicalDetail.aspx?ref=56-75-7&terms= chloramphenicol. Acessed on Dec 9th, 2015.
[8] Pubchem (2015). Available at: http://pubchem.ncbi.nlm.nih.gov/compound/chloramphenicol# section=Top; Acessed on Dec 9th, 2015.
[9] IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-present. Available at: http://monographs.iarc.fr/ENG/Classification/index.php, 50, 1–171 (1990).
[10] Brasil. Ministério da Agricultura e Abastecimento. Instrução Normativa nº 9, de 27de junho de 2003, Diário Oficial da União, Brasilia, DF, 1, 1–2 (2003).
[11] EC European Commission, Council Regulation Nº 37/2010 of 22 dec 2009: on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin., Off. J. Eur. Comm. 1–72 (2010).
[12] Brasil, Ministério da Agricultura, da Pesca e do Abastecimento. Instrução Normativa nº 13, de 15 de julho de 2015, Diário Oficial da União, Brasília, DF, 136, 5-12 (2015).
[13] Canada, List of Maximum Residue Limits for Veterinary Drugs in Foods, Health Canada, Canada, (2015). Available at: http://www.hc-sc.gc.ca/dhp-mps/vet/mrl-lmr/mrl-lmr_versus_new-nouveau-eng.php.
[14] USDA. Foreign Agricultural Services, Maximum Residue Limits (MRL) Database. (2015). Available at: http://www.fas.usda.gov/maximum-residue-limits-mrl-database.
[15] A.Q. Mauricio, E.S. Lins and M.B. Alvarenga, Anal. Chim. Acta, 637, 333–336 (2009).
[16] ANVISA. PamVet. Monitoramento de resíduos em leite exposto ao consumo, relatorio 2006-2007, 1–74 (2009).
[17] R.S. Ferreira, B.F. Spisso, I.M.C. Hora, M.A. Monteiro, M.U. Pereira, R.P. Costa and B.S. Carlos, Seg. Alim. Nutric., 19(2), 30–40 (2012).
[18] C. Pan, H. Zhang and S. Chen, Y. Xu and S. Jiang, Acta Chromatogr., 17, 320–327 (2006).
[19] D. Ortelli, P. Edder and C. Corvi, Chromatographia, 59(1/2), 61–64 (2004).
[20] A. Kaufmann and P. Butcher, Rap. Communic. Mass Spectrom., 19, 3694–3700 (2005).
[21] L.R. Guidi, P.A.S. Tette and M.B.A. Gloria, In: III Conferência Nacional sobre Defesa Agropecuária, 2012, Salvador. Anais da III Conferência Nacional sobre Defesa Agropecuária, p. 59 (2012b).
[22] EC European Commission, Commission Decision 2002/657/EC of 12 August 2002. Off. J. Eur. Communities, L221, 8–36 (2002).
[23] S.H. Monteiro, J.G. Francisco, T.F. Campion, R.F. Pimpinato and G.C.R. Moura Andrade, Aquaculture, 447, 37–43 (2015).
[24] T. Taka, M.C. Baras and Z.F. Chaudhry Bet, Food Addit. Contamin., 29(4), 596–601 (2012).
[25] R.S. Nicolich, E. Werneck-Barroso and M.A.S. Marques, Anal. Chim. Acta, 565, 97–102 (2006).
[26] F. Barreto, C. Ribeiro, R.B. Hoff and T. Dalla Costa, Food Addit. Contamin., 29(4), 550–558 (2012).
[27] H.A. Martins Júnior, O.V. Bustillos, M.A.F. Pires, D.T. Lebre and A.Y. Wang, Quim. Nova, 29(3), 586–592 (2006).
[28] L.R. Guidi, M.C.P.P. Oliveira, P.A.S. Tette and M.B.A. Gloria, In: III Conferência Nacional sobre Defesa Agropecuária, 2012, Salvador. Anais da III Conferência Nacional sobre Defesa Agropecuária, p. 58 (2012a).
[29] P.A.S. Tette, L.R. Guidi, W.P. Evangelista and M.B.A. Gloria, III Conferência Nacional sobre Defesa Agropecuária, 2012, Salvador. Anais da III Conferência Nacional sobre Defesa Agropecuária, p. 97 (2012).
[30] S.R. Rocha Siqueira, J.L. Donato, G. Nucci and F.G.R. Reyes, J. Sep. Sci., 32, 4012–4019 (2009).
[31] Z. Barganska, M. Slebioda and J. Namiesnik, Trends Anal. Chem., 30(7), 1035–1041 (2011).
[32] L. Verzegnassi, D. Royer, P. Mottier, R.H. Stadler, Food Addit. Contam., 20, 335–342 (2003).
[33] Y. Lu, Q. Shen, Z. Dai, H. Zhang, Anal. Bioanal. Chem., 398, 1819–1826 (2010).
[34] X. Shi, S. Song, A. Sun, D. Li, A. Wu, D. Zhang, Anal. Lett., 43, 2798–2807 (2010).
[35] T. Sniegocki, M. Gbylik-Sikorska and A. Posyniak, Food Control, 57, 411–418 (2015).
[36] PNCR (2015). Available at: http://www.agricultura.gov.br/portal/page/portal/Internet-MAPA/pagina-inicial/biblioteca/publicacoes. Acessed on Dec 20th, 2015.
[37] H. Tian. Chemosphere 83, 349–355 (2011).
[38] X. Peng, Z. Wang, W. Kuang, J. Tan and K. Li, Sci.Total Environ., 371, 314–322 (2006).
[39] A.J. Watkinson, E.J. Murby, D.W. Kolpin and S.D. Costanzo, Sci. Total Environ., 407, 2711–2723 (2009).
