LC-MS/MS determination of chloramphenicol in food of animal origin in Brazil

Guidi, Letícia R.; Silva, Luiza H. M.; Fernandes, Christian; Engeseth, Nicki J.

Palavras-chave: antibiotic, milk, fish, honey, liquid chromatography, mass spectrometry.

Resumo: Chloramphenicol is a highly efficient antibiotic with broad spectrum activity. It has been banned from food producing animals because of serious adverse effects to human health. Nevertheless, it is still being used in some countries because of its high efficacy and relatively low price. There is currently a minimally required performance limit (MRPL) defined at 0.3 mg/kg. This is the reason why chloramphenicol has often been analyzed by highly efficient and sensitive single residue methods. The objective of this review is to provide the state-of-art scientific knowledge on chloramphenicol, the LC-MS/MS methods used for its analysis and its occurrence in foods of animal origin in Brazil.

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