http://dx.doi.org/10.4322/sc.2016.029

Chiral separations using nano-liquid chromatography

Fanali, Chiara; D’Orazio, Giovanni; Fanali, Salvatore

Palavras-chave: microfluidic techniques, nano-liquid chromatography, capillaryliquid chromatography, enantiomers separation, chiral stationary phases.

Resumo: Microfluidic separation techniques, including electromigration and liquid chromatography have been studied, developed and applied in different fields of analytical chemistry. They can offer some advantages over conventional analytical tools such as high-performance liquid chromatography, e.g., higher mass sensitivity due to reduced chromatographic dilution, use of minute volumes of mobile phases, lower costs for both waste and organic solvent consumption and last but not list perfect coupling with mass spectrometry. Capillary/nano-liquid chromatography (CLC/nano-LC) have been recently proposed and applied to the analysis of a large number of compounds including proteins, peptides, drugs, herbicides, pesticides, enantiomers etc. In this paper principles, instrumentation and selection of experimental conditions are illustrated also presenting some selected applications to document the usefulness of these LC techniques. Advantages, limitations and future trends of CLC/nano-LC are also presented.


Referências Bibliográficas

[1] S. C. Stinson, Chem. Eng News, September 19, 38-72 (1994).
[2] B. Chankvetadze, Capillary electrophoresis in chiral analysis, John Wiley & Sons, Chichester, UK, 1997, pp. 1-555.
[3] D. W. Armstrong, Y. B. Tang, S. S. Chen, Y. W. Zhou, C. Bagwill, J. R. Chen, Anal. Chem 66, 1690-1695 (1994).
[4] S. Fanali, G. D’Orazio, K. Lomsadze, B. Chankvetadze,, J. Chromatogr. B 875, 296–303, 2008.
[5] G. Gubitz, M.G. Schmid, Chiral separation principles. An introduction in Chiral separations Methods and Protocols, G.Gubitz and M.G. Schmid, Humana Press Totowa, New Jersey, 2004, pp. 1-28.
[6] C. E. Dalgliesh, J. Chem. Soc. 137; 3940-3942 (1952).
[7] A. Rocco, Z. Aturki, S. Fanali, Trends Anal. Chem. 52; 206–225 (2013).
[8] J. P. C. Vissers, H. A. Claessens, C. A. Cramers, J. Chromatogr. A 779; 1-28 (1997).
[9] G. Guiochon, F. Gritti, J. Chromatogr. A, 1218; 1915-1938 (2011)
[10] S. Fanali, S. Rocchi, B. Chankvetadze, Electrophoresis 34; 1737-1742 (2013).
[11] G. D’Orazio, S.Fanali, J. Sep. Sci. 31; 2567-2571 (2008).
[12] S. Fanali, Z. Aturki, G. D’Orazio, A. Rocco, A. Ferranti, L. Mercolini, M. A. Raggi, J. Sep. Sci. 33; 2663-2670 (2010).
[13] T. Takeuchi, J. High Resolut. Chromatogr. 14; 560-561(1991).
[14] A. Rocco, S. Fanali, J. Sep. Sci., 32; 1696 – 1703 (2009).
[15] N. Rosales-Conrado, M.E. Leon-Gonzalez, A. Rocco, S.Fanali, Curr. Anal. Chem. 6; 209-216 (2010).
[16] A. Rocco, A. Maruška, S. Fanali, Anal. Bioanal. Chem. 402; 2935–2943 (2012).
[17] J. Vindevogel, J. van Dijck, M. Verzele, J. Chromatogr. 447; 297-303 (1988).
[18] B. Chankvetadze, C. Yamamoto, Y. Okamoto, Chemistry Letters 32; 850-851 (2003).
[19] B. Preinerstorfer, C. Hoffmann, D. Lubda, M. Lämmerhofer, W. Lindner, Electrophoresis 29; 1626-1637 (2008).
[20] G. D’Orazio, A. Cifuentes, S. Fanali, Food Chem. 108; 1114-1121 (2008).
[21] K. Si-Ahmed, F. Tazerouti, A. Y. Badjah-Hadj-Ahmed, Z. Aturki, G. D’Orazio, A. Rocco, S. J. Pharm. Biomed. Anal. 51; 225–229 (2010).
[22] S. Rocchi, C. Fanali, S. Fanali, Chirality 27; 767-772 (2015).
[23] H. Hofstetter, O. Hofstetter, V. Schurig, J. Microcol. Sep. 10; 287-291 (1998).
[24] G. Hesse, R. Hagel, Chromatographia, 6; 277-280 (1973).
[25] E. Francotte, R. M. Wolf, Chirality 3; 43-55 (1991).
[26] B. Chankvetadze, E. Yashima, Y. Okamoto, J. Chromatogr, A 694; 101-109 (1995).
[27] P. Franco, A. Senso, L. Oliveros, C. Minguillon, J. Chromatogr. A 906; 155-170 (2001).
[28] M. Gegenava, L. Chankvetadze, T. Farkas, B. Chankvetadze, J. Sep. Sci. 37; 1083–1088 (2014).
[29] K. Gogaladze, L. Chankvetadze, M. Tsintsadze, T. Farkas, B. Chankvetadze, Chirality 27; 228-234 (2015).
[30] B. Chankvetadze, I. Kartozia, Y. Okamoto, G. Blaschke, J. Sep. Sci. 24; 635-642 (2001).
[31] B Chankvetadze, I. Kartozia, C. Yamamoto, Y. Okamoto, G. Blaschke, J. Pharm. Biomed. Anal. 30; 1897–1906 (2003).
[32] B. Chankvetadze, C. Yamamoto, N. Tanaka, K. Nakanishi, Y. Okamoto, J. Sep. Sci. 27; 905–911 (2004).
[33] S. Fanali, G. D’Orazio, K. Lomsadze, S. Samakashvili, B. Chankvetadze, J. Chromatogr. A 1217; 1166-1174 (2010).
[34] S. Rocchi, S. Fanali, T. Farkas, B. Chankvetadze, J. Chromatogr. A 1363; 363-371 (2014).
[35] S. Fanali, G. D’Orazio, T. Farkas, B. Chankvetadze, J. Chromatogr. A 1269; 136–142 (2012).
[36] S. Rocchi, A. Rocco, J. J. Pesek, M. T. Matyska, D. Capitani, S. Fanali, J. Chromatogr. A 1381; 149–159 (2015).