http://dx.doi.org/10.4322/sc.2017.002
Fases estacionárias/ extratoras core-shell: desenvolvimento, características e aplicações
Ferreira, Claudio de C.; Jardim, Isabel C. S. F.
Palavras-chave: core-shell, cromatografia líquida, fase estacionária, preparo de amostra, sorvente.
Resumo: Fases estacionárias (FE) core-shell foram desenvolvidas para se tornarem fortes concorrentes às partículas sub-2 μm, empregadas em Cromatografia Líquida de Ultra Alta Eficiência (UHPLC), por fornecerem separações rápidas, com alta eficiência e sem aumento na pressão, podendo ser utilizadas em um sistema cromatográfico convencional, dispensando, dessa forma, o uso de aparelhos mais sofisticados como o utilizado em UHPLC. A morfologia das partículas core-shell é o ponto chave para o entendimento do desempenho cromatográfico atribuído à essa tecnologia. O menor caminho de difusão gerado pela fina camada (shell ) dessas partículas favorece a transferência de massa e, consequentemente, melhora a eficiência cromatográfica e diminui o tempo de análise. Essas partículas também são produzidas em escala nanométrica e aplicadas como sorventes em preparo de amostra, sendo muitas delas enquadradas na técnica de extração magnética em fase sólida (MSPE) que tem como vantagem o uso de um campo magnético para separar o sorvente do meio de extração. Existem vários métodos descritos na literatura para produção das partículas core-shell que são apresentados nesta revisão juntamente com suas características, vantagens, desvantagens e aplicações.
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